- Chicago: The Musical (2002) .... Roxie Hart
- White Oleander (2002) .... Claire Richards
- VH1 Divas Live: The One and Only Aretha Franklin (2001) (TV) .... Herself
- Bridget Jones's Diary (2001) .... Bridget Jones
- ... aka Journal de Bridget Jones, Le (2001) (France)
- 73rd Annual Academy Awards, The (2001) (TV) .... Presenter
- VH1/Vogue Fashion Awards (2000) (TV) .... Herself
- Me, Myself & Irene (2000) .... Irene P. Waters
- Nurse Betty (2000) .... Betty Sizemore
- Bachelor, The (1999) .... Anne Archer
- One True Thing (1998) .... Ellen Gulden
- Price Above Rubies, A (1998) .... Sonia Horowitz
- Deceiver (1997) .... Elizabeth
- ... aka Liar (1997)
- Jerry Maguire (1996) (as Renee Zellweger) .... Dorothy Boyd Maguire
- Whole Wide World, The (1996) .... Novalyne Price
- Empire Records (1995) .... Gina
- ... aka Empire (1995/II)
- ... aka Rock & Fun (1995)
- 8 Seconds (1994) .... Prescott Motel Buckle Bunny
- ... aka Lane Frost Story, The (1994)
- Low Life, The (1994/I) .... Poet
- Reality Bites (1994) (as Renee Zellweger) .... Tami
- Shake, Rattle and Rock! (1994) (TV) .... Susan
- Return of the Texas Chainsaw Massacre, The (1994) .... Jenny
- ... aka TCM 4 (1994) (USA: abbreviated title)
- ... aka Texas Chainsaw Massacre 4 (1994) (abbreviated title)
- ... aka Texas Chainsaw Massacre: The Next Generation, The (1997) (USA: reissue title)
- Love and a .45 (1994) .... Starlene Cheatham
- My Boyfriend's Back (1993)
- ... aka Johnny Zombie (1993)
- Murder in the Heartland (1993) (TV) .... Caril's Sister Barbara
Taste for Killing, A (1992) (TV) .... Mary Lou
Notable TV guest appearances:
- "Rove Live" (2000) playing "Herself"(episode # 2.19) 6/26/2001
- "King of the Hill" (1997) playing "Tina the "Ho""(voice) in episode: "Ho, Yeah!" (episode # 5.13) 2/25/2001
- "Married... with Children" (1987) playing "Mindy" in episode: "Top of the Heap" (episode # 5.20) 4/7/1991
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